AGING AND ALZHEIMER’S DISEASE

 

Kam K, Duffy AM, LaFrancois JJ, Scharfman HE (2016) Interictal spikes during sleep are an early defect in the Tg2576 mouse model of β-amyloid neuropathology. Sci. Rep. 6:20119. doi: 10.1038/srep20119.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730189/


Duffy AM, Morales-Corraliza J, Bermudez-Hernandez KM, Schaner MJ, Magagna-Poveda A, Mathews PM, Scharfman HE. (2014) Entorhinal cortical defects in Tg2576 mice are present as early as 2-4 months of age. Neurobiol Aging. 36:134-48.

http://www.ncbi.nlm.nih.gov/pubmed/25109765


Scharfman HE, Chao MV. (2013)  The entorhinal cortex and neurotrophin signaling in Alzheimer's disease and other disorders. Cogn Neurosci. 4:123-35.

http://www.ncbi.nlm.nih.gov/pubmed/24168199


Chin J, Scharfman HE (2013) Shared cognitive and behavioral impairments in epilepsy and Alzheimer's disease and potential underlying mechanisms. Epilepsy and Behavior. 26:343-351.

http://www.ncbi.nlm.nih.gov/pubmed/23321057


Scharfman HE (2012) Alzheimer’s disease and epilepsy: insight from animal models. Future Neurol. 7:177-192

Scharfman2012FutNeurol.pdf


Duffy AM, Schaner M, Wu S, Arevalo J-C, Arancio O, Chao MV, Scharfman HE (2011) A selective role of ARMS/kidins220 scaffold protein in spatial memory and trophic support of entorhinal and frontal cortical neurons. Exp Neurol. 229:409-420.

This paper demonstrates that ARMS is critical to the normal maintenance of cortical neurons and spatial memory in the adult mouse.  It appears to be most important to entorhinal and frontal cortical neurons, because large areas within these regions exhibited signs of oxidative stress, such as weak labeling with the antibody NeuN, damaged mitochondria, and defects in myelin. This is interesting because these areas are critical to cognition and have been shown to be vulnerable in aging and Alzheimer’s disease.  This study supports the hypothesis that neurotrophins are critical to normal aging, and suggest that ARMS could be a useful therapeutic target.

www.ncbi.nlm.nih.gov/pubmed/21419124