dentate gyrus

 


Scharfman HE. (2016) The enigmatic mossy cell of the dentate gyrus. Nat Rev Neurosci. 17:562-75. 

http://www.ncbi.nlm.nih.gov/pubmed/27466143


Scharfman HE, Storm-Mathisen J, Blackstad TW, Leergaard TB (2015) Observations on hippocampal mossy cells in mink (Neovision vision) with special reference to dendrites ascending to the granular and the molecular layers. Hippocampus. 26:229-245.

http://www.ncbi.nlm.nih.gov/pubmed/?term=scharfman%2C+blackstaad


Scharfman HE, Myers CE (2015) Corruption of the dentate gyrus by “dominant” granule cells: Implications for dentate gyrus function in health and disease. Neurobiol. Learn Mem Special Issue. 129:69-82

http://www.ncbi.nlm.nih.gov/pubmed/26391451


Scharfman HE, Bernstein HL (2015) Potential implications of a monosynaptic pathway from mossy cells to adult-born granule cells of the dentate gyrus. Frontiers Syst Neuroscience Special Issue. 9:112

http://www.ncbi.nlm.nih.gov/pubmed/26347618


Duffy AM, Schaner MJ, Chin J, Scharfman HE (2013) Expression of c-fos in hilar mossy cells of the dentate gyrus in vivo. Hippocampus.

Duffyetal2013HilarCfos.pdf

Supplemental Information:

Duffy et al 2013 Hippocampus Suppl Information.pdf


Scharfman HE, Myers CE (2013) Hilar mossy cells of the dentate gyrus: a historical perspective. Frontiers Neural Circuits. Special issue on the Dentate Gyrus

Reprint:

http://www.ncbi.nlm.nih.gov/pubmed/23420672


Myers CE, Scharfman HE (2010) Pattern separation in the dentate gyrus: a role for the backprojection. Hippocampus. 21:1190-1215.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/20683841


Myers CE, Scharfman HE (2009) A role of hilar cells in pattern separation in the dentate gyrus: a computational approach. Hippocampus. 19: 321-337.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/18958849


Scharfman HE (2007) The Dentate Gyrus: Basic Science and Clinical Implications. New YorkL Elsevier. (also Prog. Brain Res. Vol. 163)


Scharfman HE (2007) The CA3 “backprojection.” Prog. Brain Res. 163:627-637.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/17765742


Amaral DG, Scharfman HE, Levanex P (2007) The dentate gyrus; fundamental neuroanatomical organization (The dentate gyrus for dummies). Prog Brain Res. 163: 3-22

Reprint:

www.ncbi.nlm.nih.gov/pubmed/17765709


Scharfman H.E. (1999) The role of nonprincipal cells in dentate gyrus excitability and its relevance to animal models of epilepsy and temporal lobe epilepsy. In: Basic Mechanisms of the Epilepsies: Molecular and Cellular Approaches, Third edition. Eds: Delgado-Esqueta A.V., Wilson W., Olsen R.W., and Porter R.J. New York, Lippincott-Raven, pp. 805-820.

Also: Adv. Neurol. 79: 805-820.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/10514865


Jackson MB, Scharfman HE (1996) Positive feedback from hilar mossy cells to granule cells in the dentate gyrus revealed by voltage-sensitive dye and microelectrode recording. J Neurophysiol. 76: 601-616.

This study showed that in hippocampal slice one can find evidence that hilar mossy cells have an excitatory effect on granule cells. The methods used field recordings and voltage-sensitive dye imaging. This study was important because most anatomical data suggest that mossy cells only innervate granule cells that are far from te cell body of the mossy cell. They also show that at the population level, one can detect the excitatory effect of mossy cells on granule cells.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/8836247


Scharfman HE (1996) Conditions required for polysynaptic excitation of dentate granule cells by area CA3 pyramidal cells in rat hippocampal slices. Neuroscience. 72:655-668.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/9157312


Scharfman HE (1995) Electrophysiological diversity of pyramidal-shaped neurons at the granule cell layer/hilus border of the rat dentate gyrus recorded in vitro. Hippocampus. 5: 287- 305.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/8589793


Scharfman H.E. (1995) Electrophysiological evidence that dentate hilar mossy cells innervate both granule cells and interneurons. J. Neurophysiol. 74: 179-194.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/7472322


Scharfman HE (1994) EPSPs of dentate gyrus granule cells synchronized with epileptiform bursts of dentate hilar mossy cells and area CA3 pyramidal cells in disinhibited rat hippocampal slices. J. Neurosci. 14: 6041-6057.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/7931561


Scharfman HE (1994) Evidence from simultaneous intracellular recordings in rat hippocampal slices that area CA3 pyramidal cells innervate dentate hilar mossy cells. J Neurophysiol. 72:  2167-2180.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/7884451


Scharfman HE (1994) Paradoxical enhancement of GABAA receptor-mediated IPSPs of dentate granule cells by bicuculline in rat hippocampal slices. Neurosci. Lett. 168:29-33.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/8028789


Scharfman HE (1994) Synchronization of area CA3 hippocampal pyramidal cells and non- granule cells of the dentate gyrus in bicuculline-treated rat hippocampal slices. Neuroscience. 59: 245-257.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/8008190


Scharfman H.E. (1993) Pre- and postsynaptic actions of somatostatin in rat and rabbit hippocampal slices. In: Presynaptic Receptors in the CNS: Physiology and Pharmacology. Eds: Dunwiddie T. and Lovinger D. Boston, Birkäuser, pp. 42-70.

Reprint:

contact hscharfman@nki.rfmh.org


Kunkel DD, Scharfman HE, Schwartkroin PA (1993)  Electron microscopy of intracellularly labeled neurons in the hippocampal slice preparation. J. Elec. Microscop. Tech. 24:67-84.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/7679592


Scharfman HE (1993) Characteristics of spontaneous and evoked EPSPs recorded from dentate spiny hilar cells in rat hippocampal slices. J. Neurophysiol. 70: 742-757.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/8105038


Scharfman HE (1993) Spiny neurons of area CA3c in rat hippocampal slices have similar electrophysiological properties and synaptic responses despite morphological variation. Hippocampus. 3: 9-28.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/8364685


Scharfman HE (1993) Activation of dentate hilar neurons by stimulation of the fimbria in rat hippocampal slices. Neurosci. Lett. 156: 61-66.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/8105429


Scharfman H.E. (1992) Differentiation of rat dentate neurons by morphology and electrophysiology in hippocampal slices: granule cells, spiny hilar cells and aspiny, "fast- spiking" cells. In: The Dentate Gyrus and Its Role in Seizures. Eds: Ribak CE, Gall CM and Mody I. New York: Elsevier. pp. 93-109.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/1361334


Scharfman HE (1991) Dentate hilar cells with dendrites in the molecular layer have lower thresholds for synaptic activation by perforant path than granule cells. J. Neurosci. 11:1660- 1673.

Reprint:

ScharfmanJNsci1991Threshold.pdf.pdf

www.ncbi.nlm.nih.gov/pubmed/2045880


Schwartzkroin PA, Scharfman HE, Sloviter RS (1990) Similarities in circuitry between Ammon's horn and dentate gyrus: local interactions and parallel processing. Prog. Brain Res. 83: 269-287.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/1975454


Scharfman HE, Kunkel DD, Schwartzkroin PA (1990) Synaptic connections of dentate granule cells and hilar neurons established by simultaneous intracellular recording in rat hippocampal slices. Neuroscience. 37: 693-707.

Reprint:

1990 Neuroscience.pdf

www.ncbi.nlm.nih.gov/pubmed/2247219


Scharfman HE, Schwartzkroin PA (1990) Responses of the fascia dentata to prolonged repetitive stimulation. Neuroscience

Reprint:

ScharfmanSchwartzkroin1990b.pdf

www.ncbi.nlm.nih.gov/pubmed/2381513


Scharfman HE, Schwartzkroin PA (1990) Consequences of prolonged afferent stimuation of the fascia dentata: epileptiform activity in area CA3. Neuroscience.

Reprint:

ScharfmanSchwartkroin1990a.pdf.pdf

www.ncbi.nlm.nih.gov/pubmed/2381514


Scharfman HE, Schwartzkroin PA (1989) Protection of dentate hilar mossy cells from prolonged stimulation by intracellular calcium chelation. Science. 246: 257-260.

Reprint:

ScharfmanSchwartzkroin1989BAPTA.pdf.pdf

www.ncbi.nlm.nih.gov/pubmed/2508225


Scharfman HE, Schwartzkroin PA (1988) Electrophysiology of morphologically identified mossy cells of the rat dentate hilus. J. Neurosci. 8: 3412-3421.

Reprint:

ScharfmanSchwartzkroinJNsci1988MCs.pdf.pdf

www.ncbi.nlm.nih.gov/pubmed/2461436


If you can not download a file or have any questions please contact Helen Scharfman at hscharfman@nki.rfmh.org or helen.scharfman@nyumc.org