entorhinal cortex


Scharfman HE, Chao MV. (2013)  The entorhinal cortex and neurotrophin signaling in Alzheimer's disease and other disorders. Cogn Neurosci. 2013;4(3-4):123-35.


Duffy AM, Schaner M, Wu S, Arevalo J-C, Arancio O, Chao MV, Scharfman HE (2011) A selective role of ARMS/kidins220 scaffold protein in spatial memory and trophic support of entorhinal and frontal cortical neurons. Exp Neurol. 229:409-20.

This paper demonstrates that ARMS is critical to the normal maintenance of cortical neurons and spatial memory in the adult mouse.  It appears to be most important to entorhinal and frontal cortical neurons, because large areas within these regions exhibited signs of oxidative stress, such as weak labeling with the antibody NeuN, damaged mitochondria, and defects in myelin. This is interesting because these areas are critical to cognition and have been shown to be vulnerable in aging and Alzheimer’s disease.  This study supports the hypothesis that neurotrophins are critical to normal aging, and suggest that ARMS could be a useful therapeutic target.

Uncorrected proofs:


Duffy et al Second Proofs.pdf

Walling, SG, Rigoulot MA, Scharfman HE (2007) Acute and chronic changes in glycogen phosphorylase after pilocarpine--induced status epilepticus. Eur J Neurosci. 26: 178-189.


Scharfman HE (2000) Epileptogenesis in the parahippocampal region: parallels with the dentate gyrus. Ann NY Acad Sci 911: 305-327.



Scharfman HE, Witter MP, Schwarcz R (2000) The Parahippocampal Region: Implications for Neurological and Psychiatric Diseases. New York Academy of Sciences.

This book contains reviews from participants in a New York Academy of Sciences meeting held in Baltimore, MD in 2000.  The speakers were experts in the parahippocampal areas of the brain.



Scharfman HE, Goodman JH, Schwarcz R (1998) Chronic changes in synaptic responses of entorhinal and hippocampal neurons after amino-oxyacetic acid (AOAA)-induced entorhinal cortical neuron loss. J Neurophysiol. 80: 3031-3046.




Ofer AA, Scharfman HE (1997) Pretreatment with L-kynurenine, the precursor to the excitatory amino acid antagonist kynurenic acid, suppresses epileptiform activity in combined entorhinal/hippocampal slices.  Neurosci Lett. 224:115-118.



Scharfman HE (1996) Hyperexcitability of entorhinal cortex and hippocampus after application of aminooxyacetic acid (AOAA) to layer III of the rat medial entorhinal cortex in vitro. J Neurophysiol. 76: 2986-3001.