Epilepsy

 

Scharfman HE.(2015) Neuroscience. Metabolic control of epilepsy. Science. 347:1312-3.

http://www.ncbi.nlm.nih.gov/pubmed/25792315


Cho KO, Lybrand ZR, Ito N, Brulet R, Tafacory F, Zhang L, Good L, Ure K, Kernie SG, Birnbaum SG, Scharfman HE, Eisch AJ, Hsieh J. (2015) Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline. Nat Commun. 6:6606.

http://www.ncbi.nlm.nih.gov/pubmed/25808087


D'Amour J, Magagna-Poveda A, Moretto J, Friedman D, LaFrancois JJ, Pearce P, Fenton AA, MacLusky NJ, Scharfman HE (2015) Interictal spike frequency varies with ovarian cycle stage in a rat model of epilepsy. Exp Neurol. 269:102-119.

http://www.ncbi.nlm.nih.gov/pubmed/?term=Scharfman%2Cd'amour


Pearce PS, Friedman D, Lafrancois JJ, Iyengar SS, Fenton AA, Maclusky NJ, Scharfman HE.(2014) Spike-wave discharges in adult Sprague-Dawley rats and their implications for animal models of temporal lobe epilepsy. Epilepsy Behav. 32:121-31.

http://www.ncbi.nlm.nih.gov/pubmed/24534480


Fisher RS, Scharfman HE, deCurtis M. (2014) How can we identify ictal and interictal abnormal activity? Adv Exp Med Biol. 813:3-23.

http://www.ncbi.nlm.nih.gov/pubmed/25012363


Scharfman HE, Brooks-Kayal AR. (2014) Is plasticity of GABAergic mechanisms relevant to epileptogenesis? Adv Exp Med Biol. 813:133-50.


Brooks-Kayal A, et al. (2013) Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy.Epilepsia 54(Supplement 4): 44-60.

This review is a guideline for studies related to comorbidities of epilepsy. It was a product of a working group formed by the International League Against Epilepsy and American Epilepsy Society to establish guidelines for translational research in epilepsy.

Reprint:

BrooksKayal et al 2013 Epilepsia Comorbidities.pdf

Letter to the Editor:

Mazarati Letter to Editor Comorbidities Guidelines 2013.pdf


Special issue of Epilepsy & Behavior (2013): The Future of Translational Epilepsy Research. Guest Editor: Helen E. Scharfman

Preface2013EpiBeh.pdf

FInal proofs Photo Gallery.pdf


Bath KG, Scharfman HE (2013) Impact of early life exposure to antiepileptic drugs on neurobehavioral outcomes based on laboratory animal and clinical research.

Epilepsy and Behavior. 26:427-439.

Reprint:

BathScharf2013EpiBehav.pdf



Chin J, Scharfman HE (2013) Shared cognitive and behavioral impairments in epilepsy and Alzheimer's disease and potential underlying mechanisms. Epilepsy and Behavior. 26:343-351.

Reprint:

ChinandScharf2013EpiBeh.pdf


McCloskey DP, Scharfman HE (2011) Progressive potassium-dependent epileptiform burst discharges in slices from pilocarpine-treated rats with recurrent seizures. Epilepsy Res.

Reprint:

ScharfmanMcCloskey2009NgenTher.pdf


Scharfman HE (2010) Seizing an opportunity: a broader definition of epilepsy will lead to better treatment. Cerebrum.

Reprint:

www.dana.org/news/cerebrum/detail.aspx?id+29090


Scharfman HE, McCloskey DP (2010) Postnatal neurogenesis as a therapeutic target in temporal lobe epilepsy. Epi Res. 85: 150-161.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/19369038


Scharfman HE, Hintz TM, Kim M, MacLusky NJ (2009) Seizures and reproductive function: insights from an animal model. Ann Neurol 54:687-697.

Reprint:

Scharfmanetal2009AnnNeurol.pdf

www.ncbi.nlm.nih.gov/pubmed/19107990


Scharfman HE, Malthankar-Phatak GH, Friedman D, Pearce PP, McCloskey DP, Harden CJ, MacLusky NJ. (2009) A rat model of epilepsy in women: a tool to study the physiological interaction between the endocrine system and seizures. Endocrinology. 150 :4437-4452.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/19443573


Scharfman HE (2009) Neurogenesis in the dentate gyrus and its potential role in epileptogenesis. In: The Encyclopedia of Epilepsy Research. Ed: Schwartzkroin PA. New York: Elsevier.

Reprint:

contact hscharfman@nki.rfmh.org


Scharfman HE (2009) The role of neurotrophins in excitability in hippocampus and its potential relevance to epilepsy. In: The Encyclopedia of Epilepsy Research. Ed: Schwartzkroin PA. New York: Elsevier.

Reprint:

contact hscharfman@nki.rfmh.org


Nicoletti JN, Shah SK, McCloskey DP, Goodman JH, Elkady A, Atassi H, Hylton D, Rudge JS, Scharfman HE, Croll SD (2008) Vascular endothelial growth factor is up- regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus. Neuroscience, 151: 232-241.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/18065154


Walling SG, Rogoulot MA, Scharfman HE (2007) Acute and chronic changes in glycogen phosphoryase in hippocampus and entorhinal cortex after status epilepticus in the adult male rat. Eur J Neurosci. 26: 178-189.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/17614948


Scharfman HE (2007) The neurobiology of epilepsy. Curr Neurol Neurosci Rep. 7: 348-354.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/17618543


Winawer MR, Makarenko N, McClsokey DP, Hintz TM, Nair N, Palmer AA, Scharfman HE (2007) Acute and chronic responses to the convulsant pilocarpine in DBA and A/J mice. Neuroscience 149: 465-475.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/17904758


Scharfman HE, Gray WP (2007) Relevance of seizure-induced neurogenesis to te etiology of temporal lobe epilepsy. Epilepsia 48 (Suppl 2) 33-41.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/17571351


Scharfman HE, Schwarcz R (2007) Neuromodulators in seizures, epileptogenesis ,and epilepsy. In: Epilepsy: A Comprehensive Guide. Eds: Engel J, Pedley TA. New York: Lippincott-Raven.

Reprint:

ScharfmanSchwarczNeuromodRev.pdf


Scharfman HE, MacLusky NJ (2006) The influence of gonadal hormones on excitability, seizures and epilepsy in the female. Epilepsia 47:1423-1440.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/16981857


Scharfman HE, Pedley TA (2006) Temporal lobe epilepsy. In: The Neurobiology of Disease. Ed: S. Gilman. Academic press.

Reprint:

contact hscharfman@nki.rfmh.org


Scharfman HE, Gray WP (2006) NPY and plasticity in the dentate gyrus after seizures. In: NPY family of peptides in inflammation immune disorders, angiogenesis, and cancer. Eds: Zukowska Z and Feuerstein G. Switzerland: Birkhauser Verlag.

Reprint:

Scharfman and Gray 2006 EXS.pdf


Scharfman HE, Goodman JH, Rigoulot M, Berger R, Walling SW, Mercurio TM, Stormes KA, MacLusky NJ (2005) Seizure susceptibility of intact and ovariectomized female rats treated with the convulsant pilocarpine. Exp Neurol 196: 73-86.

Reprint:

ww.ncbi.nlm.nih.gov/pubmed/16084511


Scharfman HE (2005) Seizure-induced neurogenesis and its dependence on growth factors and cytokines. In: Growth Factors and Epilepsy. Eds: Binder DK, Scharfman HE. New York: Novasciences.

Reprint:

ScharfmanGFEpiRev.pdf


McCloskey DP, Croll SD, Scharfman HE (2005) Depression of synaptic transmission by vascular endothelial growth factor in adult rat hippocampus and evidence for increased efficacy after chronic seizures. J Neurosci. 25: 8889-8897.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/16192378


Croll SD, McCloskey DP, Nicoletti JN, Scharfman HE (2005) VEGF as a novel seizure therapeutic: killing two birds with one stone. In: Growth Factors in Epilepsy. Eds: Binder DK, Scharfman HE.

Reprint:

CrollGFEpiCh.pdf


Scharfman HE (2005) BDNF and epilepsy- the missing link? Epilepsy Curr. 5: 83-88.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/16145610


Scharfman HE (2004) Functional implications of seizure-induced neurogenesis. In: Recent Advances in Epilepsy Research. Eds: Binder DK, Scharfman HE. New York: Landes/Kluwer.

Reprint:

ScharfmanRecAdvEpiCh.pdf


Croll SD, Goodman JH, Scharfman HE (2004) VEGF: killing two birds with one stone. Adv Exp Med Biol. 548: 57-68.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/15250585


Scharfman HE, Sollas AL, Berger RE, Goodman JH (2003) Electrophysiological evidence of monosynaptic excitatory transmission between granule cells after seizure-induced mossy fiber sprouting. J Neurophysiol. 90: 2536-47.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/14534276


Scharfman HE (2002) Epilepsy as an example of neural plasticity. The Neuroscientist

This review addresses the idea that epilepsy is one of the best examples of neural plasticity, despite the fact that few study epilepsy to gain insight into mechanisms underlying plasticity in the CNS. 

Reprint:

ScharfmanEpiPlasticity.pdf


Schwarcz R, Bertram E, Scharfman HE (2002) Temporal lobe epilepsy: renewed emphasis on extrahippocampal areas In: Neuropsychopharmacology: Fifth Generation of Progress. 5th Edition. Eds: Davis  KL, Charney D, Coyle JT, Nemeroff C.  American College of  Neuropsychopharmacology. pp.1844-1857.

Reprint:

ACNP epilepsy review.pdf


Scharfman et al (2002) Stuctural and functional asymmetry in the dentate gyrus. J Comp Neurol.454:424–444.

This article shows that there are several differences between the two blades of the dentate gyrus  in rats that have chronic seiuzres.

Reprint:

Scharfmanetal2002UpLobladeJCompNeurol.pdf


Scharfman H.E., Smith K.S., Goodman J.H. and Sollas A.L. (2001) Survival of dentate hilar mossy cells after pilocarpine-induced seizures and their synchronized burst discharges with area CA3 pyramidal cells. Neuroscience. 104:741-759.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/11440806


Scharfman HE (2000) Epileptogenesis in the parahippocampal region: parallels with the dentate gyrus. In: The Parahippocampal Region: Basic Science and Clinical Implications. Eds: Scharfman HE, Witter MP, Schwarcz R. NY: New York Academy of Sciences.

This is a review that compares circuitry in entorhinal cortex and dentate gyrus related to their role in temporal lobe epilepsy.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/10911882


Other Epilepsy currents commentaries:

Catamenial epilepsy.

Reprint: http://www.ncbi.nlm.nih.gov/pubmed/15309068

Absence epilepsy.

Reprint: http://www.ncbi.nlm.nih.gov/pubmed/16145615

Multidrug transporters.

Reprint: http://www.ncbi.nlm.nih.gov/pubmed/15309119

GABA in granule cells.

Reprint: http://www.ncbi.nlm.nih.gov/pubmed/15309170

Neurodevelopmental models of epilepsy.

Reprint: http://www.ncbi.nlm.nih.gov/pubmed/15309141

Reelin.

Reprint: http://www.ncbi.nlm.nih.gov/pubmed/15309117

BDNF.

Reprint: http://www.ncbi.nlm.nih.gov/pubmed/15309154

Pacemaker channels.

Reprint: http://www.ncbi.nlm.nih.gov/pubmed/15309154


Scharfman H.E. (1999) The role of nonprincipal cells in dentate gyrus excitability and its relevance to animal models of epilepsy and temporal lobe epilepsy. In: Basic Mechanisms of the Epilepsies: Molecular and Cellular Approaches, Third edition. Eds: Delgado-Esqueta A.V., Wilson W., Olsen R.W., and Porter R.J. New York, Lippincott-Raven, pp. 805-820.

Also: Adv. Neurol. 79: 805-820.

Reprint:

www.ncbi.nlm.nih.gov/pubmed/10514865


If you can not download a file or have any questions please contact Helen Scharfman at hscharfman@nki.rfmh.org or helen.scharfman@nyumc.org