welcome to the scharfman lab
welcome to the scharfman lab
Neuronal excitability and its role in disorders of the nervous system
Research topics:
Mechanisms of neuronal excitability and plasticity
Hippocampus; dentate gyrus; entorhinal cortex; “limbic” circuits
Dysfunction in ‘complex’ disorders
Epilepsy
Aging and Alzheimer’s disease
Neuroendocrinology; sex differences
Current research “streams”:
Neurotrophins
Estrogen and androgen actions
mediated by brain-derived
neurotrophic factor (BDNF)
Neurogenesis in the adult dentate
gyrus
Mossy cells of the dentate gyrus
overview
PEOPLE
PUBLICATIONS
CONTACT INFORMATION
Top left: A “mossy” cell of the dentate gyrus hilus.
Top right: A GABAergic interneuron in the dentate gyrus. Bottom: A seizure-like event, recorded in a hippocampal slice after exposure to the neurotrophin BDNF and a GABA receptor antagonist. See Publications (topics: dentate gyrus, epilepsy) for more information.
From top right, clockwise: Aine Duffy, Korey Kam, Hannah Bernstein, Swati Jain, John LaFrancois, Jillian Moretto, Helen Scharfman