Magagna-Proveda A, Moretto JN, Scharfman HE. (2017) Increased gyrification and aberrant adult neurogenesis of the dentate gyrus in adult rats. Brain Structure and Function. 222:4219-4237.

Bermudez-Hernandez K, Lu YL, Moretto J, Jain S, LaFrancois JJ, Duffy AM, Scharfman HE. (2017) Hilar granule cells of the mouse dentate gyrus: effects of age, septotemporal location, strain, and selective deletion of the proapoptotic gene BAX. Brain Structure and Function 222:3147-3161.

Drew LJ, Kheirbek MA, Luna VM, Denny CA, Cloidt MA, Wu MV, Jain S, Scharfman HE, Hen R.

(2016) Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons. Hippocampus. 26:763-778.

Cho KO, Lybrand ZR, Ito N, Brulet R, Tafacory F, Zhang L, Good L, Ure K, Kernie SG, Birnbaum SG, Scharfman HE, Eisch AJ, Hsieh J. (2015) Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline. Nat Commun. 6:6606.

Iyengar SS, LaFrancois JJ, Friedman D, Drew LJ, Denny CA, Burghardt NS, Wu MV, Hsieh J, Hen  R, Scharfman HE. (2015) Suppression of adult neurogenesis increases the acute effects of kainic acid. Exp Neurol. 264:135-49.


Myers CE, Bermudez-Hernandez K, Scharfman HE (2013) The influence of ectopic migration of granule cells into the hilus on dentate gyrus-CA3 function. PLoS One. 8: e68208.


Scharfman HE, Pierce JP (2012) New insights into the role of hilar ectopic granule cells in the dentate gyrus based on quantitative anatomic analysis and three-dimensional reconstruction. Epilepsia 53 (S1):109-115. Special issue to honor Jurgen Wenzel.



Pierce JP, McCloskey DP, Scharfman HE (2011) The morphometry of hilar ectopic granule cells. J Comp Neurol. 519: 1196-1218.

This study used quantitative methods to analyze the morphometry of ectopic granule cells in the hilus that were labeled using Neurobiotin in hippocampal slices.


Pierce et al 2011JCompNeurol.pdf

Scharfman HE, McCloskey DP (2009) Postnatal neurogenesis as a therapeutic target for epilepsy. Epi Res. 85: 150-161.

This review discusses the new ideas for therapeutics in temporal lobe epilepsy that are suggested by the studies of postnatal neurogenesis in epilepsy.



Scharfman HE, Hen R (2007) Are more neurons always better? Science 315: 316-318.

This commentary points out that many of the recent ideas about increasing postnatal neurogenesis to improve brain health in adulthood should be considered with more caution.



Pierce JP, Punsoni M, McCloskey DP, Scharfman HE (2007)Mossy cell axon synaptic contacts on ectopic granule cells that are born following pilocarpine-induced seizures. Neuroscience Lett. 422: 136-140.

This electron microscopy study characterizes some of the circuitry of ectopic granule cells in the epileptic rat that had not been previously characterized before.


Scharfman HE, Gray WP (2007) Relevance of seizure-induced neurogenesis to the etiology of temporal lobe epilepsy. Epilepsia. 48 (Suppl 2):33-41.

This review addresses the idea that increasing neurogenesis in the dentate gyrus may be useful in temporal lobe epilepsy.


Howell OW, Silva S, Scharfman HE, Sosunov AA, Zaben M, McKhann GM, Lawskowski A, Gray WP (2006) Neuropeptide Y is important for basal and seizure induced precursor cell proliferation in the hippocampus. Neurobiol Dis. 26: 174-188.


Howell OW, Doyle K, Goodman JH, Scharfman HE, Herzog H, Pringle A, BeckSickinger AG, Gray WP (2005) Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus. J Neurochem 93: 560-570.


Scharfman HE, McCloskey DP (2006)  Ectopic granule cells of the rat dentate gyrus. Dev. Neurosci. 29: 14-27.

This review article discusses published studies about ectopic granule cells in the dentate gyrus.



McCloskey DP, Hintz TM, Pierce JP, Scharfman HE (2006) Stereological methods reveal the robust size and stability of ectopic hilar granule cells following pilocarpine-induced status epilepticus in the adult rat. Eur J Neurosci 24: 2203-2210.



Scharfman et al (2005) Increased neurogenesis and ectopic granule cells after intrahippocampal BDNF infusion in adult rats. Exp Neurol. 192: 348-356.

This paper used infusion of BDNF into the dentate gyrus to determine if this treatment was sufficient to increase neurogenesis and ectopic granule cells.  Neurogenesis in the dentate gyrus was increased, and ectopic granule cells were observed in the hilus, supporting the hypothesis that BDNF plays a potentially important role.


Pierce JP, Melton J, Punsoni M, McCloskey DP, Scharfman HE (2005) Mossy fibers are the primary source of afferent input to ectopic granule cells that are born after pilocarpine-induced seizures. Exp Neurol. 196:316-331.

This study used electron microscopy of ectopic granule cells to determine their afferents and efferents.



Scharfman HE (2004) Functional implications of seizure-induced neurogenesis. In: Recent Advances in Epilepsy Research. Eds: Binder DK, Scharfman HE. New York: Landes/Kluwer.

This review article discusses the discovery of ectopic granule cells in the epileptic rat and their significance to hippocampal function and epilepsy.


Howell OW, Scharfman HE, Beck-Sickinger AG, Herzog HH and Gray WP (2003) Neuropeptide Y is neuroproliferative for hippocampal stem cells and neuroblasts. J. Neurochem. 86: 646-659.


Scharfman HE, Sollas AL, Berger RE, Gpoodman JH, Pierce JP (2003) Perforant path activation o ectopic granue cells that are born after pilocarpine-induced status epilepticus. Neuroscience 121: 1017-1029.

This paper characterized the responses of ectopic granule cells from epileptic rats with normal granule cells and also studied some of the rare ectopic granule cells of the nornal rat.


Scharfman HE, Goodman JH, Sollas AL (2001) Spontaneous recurrent seizures after pilocarpine-induced status epilepticus activate calbindin-immunoreactive hilar cells of the rat dentate gyrus.

Neuroscience 111: 71-81.


Scharfman HE et al (2000) Granule-like hilar neurons in the dentate gyrus: functional implications of seizure-induced neurogenesis. J Neurosci  20: 6144-6158.

This study showed for the first time that neurons born in the adult dentate gyrus had normal functional properties of neurons, with responses to afferent input, action potentials, and other attributes. It also showed that neurons born after seizure induction could mismigrate into the hilus, and display abnormal firing that was synchronized with area CA3 pyramidal cells.



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